CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.20 | Up-down Bundle |
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1.20.920 | Histone Acetyltransferase; Chain A |
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1.20.920.10 | Bromodomain-like |
Domain Context
CATH Clusters
Superfamily | Bromodomain-like |
Functional Family | Histone acetyltransferase KAT2B |
Enzyme Information
2.3.1.48 |
Histone acetyltransferase.
based on mapping to UniProt Q92831
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
-!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins.
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2.3.1.57 |
Diamine N-acetyltransferase.
based on mapping to UniProt Q92831
Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.
-!- Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)- acetylspermidine and N(8)-acetylspermidine.
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UniProtKB Entries (1)
Q92831 |
KAT2B_HUMAN
Homo sapiens
Histone acetyltransferase KAT2B
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PDB Structure
PDB | 5FE6 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain.
J.Med.Chem.
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