CATH Domain 5f9eB02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Protein kinase C, theta

Enzyme Information

2.7.11.13

Protein kinase C.

based on mapping to UniProt Q04759

ATP + a protein = ADP + a phosphoprotein.

-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q04759

KPCT_HUMAN

Homo sapiens

Protein kinase C theta type

PDB Structure

PDB	5F9E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKC theta inhibitors. Katoh, T., Takai, T., Yukawa, T., Tsukamoto, T., Watanabe, E., Mototani, H., Arita, T., Hayashi, H., Nakagawa, H., Klein, M.G., Zou, H., Sang, B.C., Snell, G., Nakada, Y. Bioorg.Med.Chem.