CATH Domain 5f03B01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Tryptase beta-2

Enzyme Information

3.4.21.59

Tryptase.

based on mapping to UniProt Q15661

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.

-!- Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. -!- Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

Q15661

TRYB1_HUMAN

Homo sapiens

Tryptase alpha/beta-1

PDB Structure

PDB	5F03
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A Real-World Perspective on Molecular Design. Kuhn, B., Guba, W., Hert, J., Banner, D., Bissantz, C., Ceccarelli, S., Haap, W., Korner, M., Kuglstatter, A., Lerner, C., Mattei, P., Neidhart, W., Pinard, E., Rudolph, M.G., Schulz-Gasch, T., Woltering, T., Stahl, M. J.Med.Chem.