CATH Domain 5eydA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Hepatocyte growth factor receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P08581

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08581

MET_HUMAN

Homo sapiens

Hepatocyte growth factor receptor

PDB Structure

PDB	5EYD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity. Boezio, A.A., Copeland, K.W., Rex, K., K Albrecht, B., Bauer, D., Bellon, S.F., Boezio, C., Broome, M.A., Choquette, D., Coxon, A., Dussault, I., Hirai, S., Lewis, R., Lin, M.H., Lohman, J., Liu, J., Peterson, E.A., Potashman, M., Shimanovich, R., Teffera, Y., Whittington, D.A., Vaida, K.R., Harmange, J.C. J.Med.Chem.