CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.470 | Uracil-DNA Glycosylase, subunit E | |
3.40.470.10 | Uracil-DNA glycosylase-like domain |
Domain Context
CATH Clusters
Superfamily | Uracil-DNA glycosylase-like domain |
Functional Family | Uracil-DNA glycosylase |
Enzyme Information
3.2.2.27 |
Uracil-DNA glycosylase.
based on mapping to UniProt P12295
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.
-!- Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. -!- Uracil-DNA glycosylase (EC 3.2.2.27) and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolyzing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalyzing the removal of mis-incorporated uracil from DNA.
|
UniProtKB Entries (1)
P12295 |
UNG_ECOLI
Escherichia coli K-12
Uracil-DNA glycosylase
|
PDB Structure
PDB | 5EUG |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.
Proteins
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