CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61

Enzyme Information

2.1.1.220
tRNA (adenine(58)-N(1))-methyltransferase.
based on mapping to UniProt P46959
S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA.
-!- The enzyme specifically methylates adenine(58) in tRNA. -!- The methylation of A(58) is critical for maintaining the stability of initiator tRNA(Met) in yeast. -!- Formerly EC 2.1.1.36.

UniProtKB Entries (1)

P46959
TRM61_YEAST
Saccharomyces cerevisiae S288C
TRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61

PDB Structure

PDB 5ERG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae.
Wang, M., Zhu, Y., Wang, C., Fan, X., Jiang, X., Ebrahimi, M., Qiao, Z., Niu, L., Teng, M., Li, X.
Sci Rep
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