CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.120 | Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 |
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3.40.120.10 | Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 |
Domain Context
CATH Clusters
Superfamily | Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 |
Functional Family | Phosphoglucomutase 5 |
Enzyme Information
5.4.2.2 |
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
based on mapping to UniProt P36871
Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
-!- Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate. -!- This bisphosphate is an intermediate in the reaction, being formed by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization. -!- Also, more slowly, catalyzes the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate. -!- Cf. EC 5.4.2.5. -!- Formerly EC 2.7.5.1.
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UniProtKB Entries (1)
P36871 |
PGM1_HUMAN
Homo sapiens
Phosphoglucomutase-1
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PDB Structure
PDB | 5EPC |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency.
J.Mol.Biol.
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