1 keywords

CATH Domain 5dufA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.226 2-enoyl-CoA Hydratase; Chain A, domain 1
Homologous Superfamily 3.90.226.10 2-enoyl-CoA Hydratase; Chain A, domain 1

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family Probable enoyl-CoA hydratase echA6

Enzyme Information

4.2.1.17
Enoyl-CoA hydratase.
based on mapping to UniProt P9WNP1
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O.
-!- Acts in the reverse direction. -!- With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74).

UniProtKB Entries (1)

P9WNP1
ECHA6_MYCTU
Mycobacterium tuberculosis H37Rv
Probable enoyl-CoA hydratase echA6

PDB Structure

PDB 5DUF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria.
Cox, J.A., Abrahams, K.A., Alemparte, C., Ghidelli-Disse, S., Rullas, J., Angulo-Barturen, I., Singh, A., Gurcha, S.S., Nataraj, V., Bethell, S., Remuinan, M.J., Encinas, L., Jervis, P.J., Cammack, N.C., Bhatt, A., Kruse, U., Bantscheff, M., Futterer, K., Barros, D., Ballell, L., Drewes, G., Besra, G.S.
Nat Microbiol