CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.10 | Orthogonal Bundle |
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1.10.390 | Neutral Protease; domain 2 |
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1.10.390.10 | Neutral Protease Domain 2 |
Domain Context
CATH Clusters
Superfamily | Neutral Protease Domain 2 |
Functional Family | Thermolysin |
Enzyme Information
3.4.24.27 |
Thermolysin.
based on mapping to UniProt P00800
Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe.
-!- A thermostable extracellular metalloendopeptidase containing four calcium ions. -!- Enzymes that may be species variants of thermolysin are reported from Micrococcus caseolyticus and Aspergillus oryzae. -!- Closely related but distinct enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin and mycolysin. -!- Belongs to peptidase family M4. -!- Formerly EC 3.4.24.4.
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UniProtKB Entries (1)
P00800 |
THER_BACTH
Bacillus thermoproteolyticus
Thermolysin
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PDB Structure
PDB | 5DPF |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Thermodynamics of protein-ligand interactions as a reference for computational analysis: how to assess accuracy, reliability and relevance of experimental data.
J. Comput. Aided Mol. Des.
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