CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.510 | Transferase(Phosphotransferase); domain 1 |
|
1.10.510.10 | Transferase(Phosphotransferase) domain 1 |
Domain Context
CATH Clusters
| Superfamily | Transferase(Phosphotransferase) domain 1 |
| Functional Family | Serine/threonine-protein kinase Nek7 |
Enzyme Information
| 2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q8TDX7
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
UniProtKB Entries (2)
| Q8K1R7 |
NEK9_MOUSE
Mus musculus
Serine/threonine-protein kinase Nek9
|
| Q8TDX7 |
NEK7_HUMAN
Homo sapiens
Serine/threonine-protein kinase Nek7
|
PDB Structure
| PDB | 5DE2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.
Nat Commun
|