CATH Domain 5d7dA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.565	Heat Shock Protein 90
	3.30.565.10	Histidine kinase-like ATPase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Histidine kinase-like ATPase, C-terminal domain
Functional Family

Enzyme Information

5.6.2.3

DNA topoisomerase (ATP-hydrolyzing).

based on mapping to UniProt P0A0K8

ATP-dependent breakage, passage and rejoining of double-stranded DNA.

-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P0A0K8

GYRB_STAAU

Staphylococcus aureus

DNA gyrase subunit B

PDB Structure

PDB	5D7D
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors. Zhang, J., Yang, Q., Romero, J.A., Cross, J., Wang, B., Poutsiaka, K.M., Epie, F., Bevan, D., Wu, Y., Moy, T., Daniel, A., Chamberlain, B., Carter, N., Shotwell, J., Arya, A., Kumar, V., Silverman, J., Nguyen, K., Metcalf, C.A., Ryan, D., Lippa, B., Dolle, R.E. Acs Med.Chem.Lett.