CATH Domain 5d1uA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.390	Collagenase (Catalytic Domain)
	3.40.390.10	Collagenase (Catalytic Domain)

Domain Context

CATH Clusters

Superfamily	Collagenase (Catalytic Domain)
Functional Family

Enzyme Information

3.4.24.83

Anthrax lethal factor endopeptidase.

based on mapping to UniProt P15917

Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases.

-!- From the bacterium Bacilus anthracis that causes anthrax. -!- One of three proteins that are collectively termed anthrax toxin. -!- Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases. -!- Belongs to peptidase family M34.

UniProtKB Entries (1)

P15917

LEF_BACAN

Bacillus anthracis

Lethal factor

PDB Structure

PDB	5D1U
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates. Kurbanov, E.K., Chiu, T.L., Solberg, J., Francis, S., Maize, K.M., Fernandez, J., Johnson, R.L., Hawkinson, J.E., Walters, M.A., Finzel, B.C., Amin, E.A. J.Med.Chem.