CATH Domain 5czvA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.300	GMP Synthetase; Chain A, domain 3
	3.30.300.320

Domain Context

CATH Clusters

Superfamily	3.30.300.320
Functional Family	Neurogenic locus notch 1

Enzyme Information

UniProtKB Entries (1)

NOTC3_HUMAN

Homo sapiens

Neurogenic locus notch homolog protein 3

PDB Structure

PDB	5CZV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Bernasconi-Elias, P., Hu, T., Jenkins, D., Firestone, B., Gans, S., Kurth, E., Capodieci, P., Deplazes-Lauber, J., Petropoulos, K., Thiel, P., Ponsel, D., Hee Choi, S., LeMotte, P., London, A., Goetcshkes, M., Nolin, E., Jones, M.D., Slocum, K., Kluk, M.J., Weinstock, D.M., Christodoulou, A., Weinberg, O., Jaehrling, J., Ettenberg, S.A., Buckler, A., Blacklow, S.C., Aster, J.C., Fryer, C.J. Oncogene