CATH Domain 5ctrC01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.2230	DUSP-like
	3.30.2230.10	DUSP-like

Domain Context

CATH Clusters

Superfamily	DUSP-like
Functional Family	ubiquitin carboxyl-terminal hydrolase 15 isoform X1

Enzyme Information

3.4.19.12

Ubiquitinyl hydrolase 1.

based on mapping to UniProt Q13107

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Q13107

UBP4_HUMAN

Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 4

PDB Structure

PDB	5CTR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3 Park, J.K., Das, T., Song, E.J., Kim, E.E. Nucleic Acids Res.