CATH Domain 5cprB02

Superfamily	SET domain
Functional Family	Histone-lysine N-methyltransferase

2.1.1.43

Histone-lysine N-methyltransferase.

based on mapping to UniProt Q4FZB7

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

KMT5B_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase KMT5B

PDB	5CPR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Bromberg, K.D., Mitchell, T.R., Upadhyay, A.K., Jakob, C.G., Jhala, M.A., Comess, K.M., Lasko, L.M., Li, C., Tuzon, C.T., Dai, Y., Li, F., Eram, M.S., Nuber, A., Soni, N.B., Manaves, V., Algire, M.A., Sweis, R.F., Torrent, M., Schotta, G., Sun, C., Michaelides, M.R., Shoemaker, A.R., Arrowsmith, C.H., Brown, P.J., Santhakumar, V., Martin, A., Rice, J.C., Chiang, G.G., Vedadi, M., Barsyte-Lovejoy, D., Pappano, W.N. Nat. Chem. Biol.