CATH Domain 5cprB01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.10	Arc Repressor Mutant, subunit A
	1.10.10.1700	Histone-lysine N-methyltransferase

Domain Context

CATH Clusters

Superfamily	Histone-lysine N-methyltransferase
Functional Family	Histone-lysine N-methyltransferase

Enzyme Information

2.1.1.43

Histone-lysine N-methyltransferase.

based on mapping to UniProt Q4FZB7

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

KMT5B_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase KMT5B

PDB Structure

PDB	5CPR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Bromberg, K.D., Mitchell, T.R., Upadhyay, A.K., Jakob, C.G., Jhala, M.A., Comess, K.M., Lasko, L.M., Li, C., Tuzon, C.T., Dai, Y., Li, F., Eram, M.S., Nuber, A., Soni, N.B., Manaves, V., Algire, M.A., Sweis, R.F., Torrent, M., Schotta, G., Sun, C., Michaelides, M.R., Shoemaker, A.R., Arrowsmith, C.H., Brown, P.J., Santhakumar, V., Martin, A., Rice, J.C., Chiang, G.G., Vedadi, M., Barsyte-Lovejoy, D., Pappano, W.N. Nat. Chem. Biol.