CATH Domain 5bvkA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Epithelial discoidin domain-containing receptor 1

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt Q08345

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q08345

DDR1_HUMAN

Homo sapiens

Epithelial discoidin domain-containing receptor 1

PDB Structure

PDB	5BVK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors. Murray, C.W., Berdini, V., Buck, I.M., Carr, M.E., Cleasby, A., Coyle, J.E., Curry, J.E., Day, J.E., Day, P.J., Hearn, K., Iqbal, A., Lee, L.Y., Martins, V., Mortenson, P.N., Munck, J.M., Page, L.W., Patel, S., Roomans, S., Smith, K., Tamanini, E., Saxty, G. Acs Med.Chem.Lett.