CATH Domain 5bv7A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Phosphatidylcholine-sterol acyltransferase

Enzyme Information

2.3.1.43

Phosphatidylcholine--sterol O-acyltransferase.

based on mapping to UniProt P04180

Phosphatidylcholine + a sterol = 1-acylglycerophosphocholine + a sterol ester.

-!- Palmitoyl, oleoyl, and linoleoyl can be transferred; a number of sterols, including cholesterol, can act as acceptors. -!- The bacterial enzyme also catalyzes the reactions of EC 3.1.1.4 and EC 3.1.1.5.

UniProtKB Entries (1)

P04180

LCAT_HUMAN

Homo sapiens

Phosphatidylcholine-sterol acyltransferase

PDB Structure

PDB	5BV7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism. Gunawardane, R.N., Fordstrom, P., Piper, D.E., Masterman, S., Siu, S., Liu, D., Brown, M., Lu, M., Tang, J., Zhang, R., Cheng, J., Gates, A., Meininger, D., Chan, J., Carlson, T., Walker, N., Schwarz, M., Delaney, J., Zhou, M. J.Biol.Chem.