CATH Domain 5afwA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
	2.40.50.40

Domain Context

CATH Clusters

Superfamily	2.40.50.40
Functional Family	Chromodomain-helicase-DNA-binding protein 2 isoform 1

Enzyme Information

3.6.4.12

DNA helicase.

based on mapping to UniProt O14646

ATP + H(2)O = ADP + phosphate.

-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

O60341

KDM1A_HUMAN

Homo sapiens

Lysine-specific histone demethylase 1A

PDB Structure

PDB	5AFW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Assembly of Methylated Kdm1A and Chd1 Drives Androgen Receptor-Dependent Transcription and Translocation. Metzger, E., Willmann, D., Mcmillan, J., Forne, I., Metzger, P., Gerhardt, S., Petroll, K., Von Maessenhausen, A., Urban, S., Schott, A., Espejo, A., Eberlin, A., Wohlwend, D., Schule, K.M., Schleicher, M., Perner, S., Bedford, M.T., Jung, M., Dengjel, J., Flaig, R., Imhof, A., Einsle, O., Schule, R. Nat.Struct.Mol.Biol.