1 keywords

CATH Domain 5ae1D01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.43 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2
Homologous Superfamily 3.30.43.10 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2

Domain Context

CATH Clusters

Superfamily Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2
Functional Family Alkylglycerone-phosphate synthase

Enzyme Information

2.5.1.26
Alkylglycerone-phosphate synthase.
based on mapping to UniProt P97275
1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion.
-!- The ester-linked fatty acid of the substrate is cleaved and replaced by a long-chain alcohol in an ether linkage.

UniProtKB Entries (1)

P97275
ADAS_CAVPO
Cavia porcellus
Alkyldihydroxyacetonephosphate synthase, peroxisomal

PDB Structure

PDB 5AE1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Inhibitors for the Ether Lipid-Generating Enzyme Agps as Anti-Cancer Agents.
Piano, V., Benjamin, D.I., Valente, S., Nenci, S., Marrocco, B., Mai, A., Aliverti, A., Nomura, D.K., Mattevi, A.
Acs Chem.Biol.