1 keywords

CATH Domain 5a86B00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.565 Retinoid X Receptor
Homologous Superfamily 1.10.565.10 Retinoid X Receptor

Domain Context

CATH Clusters

Superfamily Retinoid X Receptor
Functional Family Nuclear receptor subfamily 1 group I member 2

Enzyme Information

UniProtKB Entries (1)

O75469
NR1I2_HUMAN
Homo sapiens
Nuclear receptor subfamily 1 group I member 2

PDB Structure

PDB 5A86
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity.
Hennessy, E.J., Oza, V.B., Adam, A., Byth, K., Castriotta, L., Grewal, G., Hamilton, G., Kamhi, V.M., Lewis, P., Li, D., Lyne, P.D., Oster, L., Rooney, M.T., Saeh, J.C., Sha, L., Su, Q., Wen, S., Xue, Y., Yang, B.
J.Med.Chem.