CATH Domain 4zgxL00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.630	Cytochrome p450
	1.10.630.10	Cytochrome P450

Domain Context

CATH Clusters

Superfamily	Cytochrome P450
Functional Family	Cholesterol side-chain cleavage enzyme, mitochondrial

Enzyme Information

1.14.15.5	Corticosterone 18-monooxygenase. based on mapping to UniProt P19099 Corticosterone + 2 reduced adrenodoxin + O(2) + 2 H(+) = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H(2)O.
1.14.15.4	Steroid 11-beta-monooxygenase. based on mapping to UniProt P19099 A steroid + 2 reduced adrenodoxin + O(2) + 2 H(+) = an 11-beta- hydroxysteroid + 2 oxidized adrenodoxin + H(2)O. -!- Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone. -!- Formerly EC 1.14.1.6 and EC 1.99.1.7.

UniProtKB Entries (1)

C11B2_HUMAN

Homo sapiens

Cytochrome P450 11B2, mitochondrial

PDB Structure

PDB	4ZGX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys. Martin, R.E., Aebi, J.D., Hornsperger, B., Krebs, H.J., Kuhn, B., Kuglstatter, A., Alker, A.M., Marki, H.P., Muller, S., Burger, D., Ottaviani, G., Riboulet, W., Verry, P., Tan, X., Amrein, K., Mayweg, A.V. J.Med.Chem.