CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.630 | Cytochrome p450 |
|
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
| Superfamily | Cytochrome P450 |
| Functional Family | Cholesterol side-chain cleavage enzyme, mitochondrial |
Enzyme Information
| 1.14.15.5 |
Corticosterone 18-monooxygenase.
based on mapping to UniProt P19099
Corticosterone + 2 reduced adrenodoxin + O(2) + 2 H(+) = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H(2)O.
|
| 1.14.15.4 |
Steroid 11-beta-monooxygenase.
based on mapping to UniProt P19099
A steroid + 2 reduced adrenodoxin + O(2) + 2 H(+) = an 11-beta- hydroxysteroid + 2 oxidized adrenodoxin + H(2)O.
-!- Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone. -!- Formerly EC 1.14.1.6 and EC 1.99.1.7.
|
UniProtKB Entries (1)
| P19099 |
C11B2_HUMAN
Homo sapiens
Cytochrome P450 11B2, mitochondrial
|
PDB Structure
| PDB | 4ZGX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.
J.Med.Chem.
|