CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.50 | 3-Layer(bba) Sandwich |
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3.50.50 | FAD/NAD(P)-binding domain |
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3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
Superfamily | FAD/NAD(P)-binding domain |
Functional Family | Renalase |
Enzyme Information
1.6.3.5 |
Renalase.
based on mapping to UniProt Q48MT7
(1) 1,2-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2). (2) 1,6-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2).
-!- Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta- NAD(P)(+). -!- These isomeric forms, generated by nonspecific reduction of beta- NAD(P)(+) or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.
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UniProtKB Entries (1)
Q48MT7 |
RNLS_PSE14
Pseudomonas savastanoi pv. phaseolicola 1448A
Renalase
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PDB Structure
PDB | 4ZCC |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Bacterial Renalase: Structure and Kinetics of an Enzyme with 2- and 6-Dihydro-beta-NAD(P) Oxidase Activity from Pseudomonas phaseolicola.
Biochemistry
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