CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.420 | Nucleotidyltransferase; domain 5 |
|
3.30.420.10 | Ribonuclease H-like superfamily/Ribonuclease H |
Domain Context
CATH Clusters
| Superfamily | Ribonuclease H-like superfamily/Ribonuclease H |
| Functional Family | Three prime repair exonuclease 1 |
Enzyme Information
| 3.1.11.2 |
Exodeoxyribonuclease III.
based on mapping to UniProt Q91XB0
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
-!- Preference for double-stranded DNA. -!- Has endonucleolytic activity near apurinic sites on DNA. -!- Similar enzyme: Haemophilus influenzae exonuclease. -!- Formerly EC 3.1.4.27.
|
UniProtKB Entries (1)
| Q91XB0 |
TREX1_MOUSE
Mus musculus
Three-prime repair exonuclease 1
|
PDB Structure
| PDB | 4YNQ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.
Proc.Natl.Acad.Sci.USA
|
