CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-/4-kinase, catalytic domain
Functional Family Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit

Enzyme Information
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt P42336
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P42336
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC and EC

UniProtKB Entries (1)

Homo sapiens
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

PDB Structure

External Links
Primary Citation
Discovery of a Potent Class of PI3K alpha Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).
Yang, H., Medeiros, P.F., Raha, K., Elkins, P., Lind, K.E., Lehr, R., Adams, N.D., Burgess, J.L., Schmidt, S.J., Knight, S.D., Auger, K.R., Schaber, M.D., Franklin, G.J., Ding, Y., DeLorey, J.L., Centrella, P.A., Mataruse, S., Skinner, S.R., Clark, M.A., Cuozzo, J.W., Evindar, G.
Acs Med.Chem.Lett.