1 keywords

CATH Domain 4yk0A00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.920 Histone Acetyltransferase; Chain A
Homologous Superfamily 1.20.920.10 Bromodomain-like

Domain Context

CATH Clusters

Superfamily Bromodomain-like
Functional Family Histone acetyltransferase p300

Enzyme Information

2.3.1.48
Histone acetyltransferase.
based on mapping to UniProt Q92793
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
-!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins.

UniProtKB Entries (1)

Q92793
CBP_HUMAN
Homo sapiens
CREB-binding protein

PDB Structure

PDB 4YK0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
Ghosh, S., Taylor, A., Chin, M., Huang, H.R., Conery, A.R., Mertz, J.A., Salmeron, A., Dakle, P.J., Mele, D., Cote, A., Jayaram, H., Setser, J.W., Poy, F., Hatzivassiliou, G., DeAlmeida-Nagata, D., Sandy, P., Hatton, C., Romero, F.A., Chiang, E., Reimer, T., Crawford, T., Pardo, E., Watson, V.G., Tsui, V., Cochran, A.G., Zawadzke, L., Harmange, J.C., Audia, J.E., Bryant, B.M., Cummings, R.T., Magnuson, S.R., Grogan, J.L., Bellon, S.F., Albrecht, B.K., Sims, R.J., Lora, J.M.
J.Biol.Chem.