CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.33 | M1 Pyruvate Kinase; Domain 3 |
|
2.40.33.10 | PK beta-barrel domain-like |
Domain Context
CATH Clusters
| Superfamily | PK beta-barrel domain-like |
| Functional Family | Pyruvate kinase PKM |
Enzyme Information
| 2.7.1.40 |
Pyruvate kinase.
based on mapping to UniProt P14618
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).
|
UniProtKB Entries (1)
| P14618 |
KPYM_HUMAN
Homo sapiens
Pyruvate kinase PKM
|
PDB Structure
| PDB | 4YJ5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation
Commun Biol
|
