1 keywords

CATH Domain 4yj5D03

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.40 Beta Barrel
Topology 2.40.33 M1 Pyruvate Kinase; Domain 3
Homologous Superfamily 2.40.33.10 PK beta-barrel domain-like

Domain Context

CATH Clusters

Superfamily PK beta-barrel domain-like
Functional Family Pyruvate kinase PKM

Enzyme Information

2.7.1.40
Pyruvate kinase.
based on mapping to UniProt P14618
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).

UniProtKB Entries (1)

P14618
KPYM_HUMAN
Homo sapiens
Pyruvate kinase PKM

PDB Structure

PDB 4YJ5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation
Chen, T.J., Wang, H.J., Liu, J.S., Cheng, H.H., Hsu, S.C., Wu, M.C., Lu, C.H., Wu, Y.F., Wu, J.W., Liu, Y.Y., Kung, H.J., Wang, W.C.
Commun Biol