CATH Domain 4yhjA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	G protein-coupled receptor kinase

Enzyme Information

2.7.11.16

[G-protein-coupled receptor] kinase.

based on mapping to UniProt P32298

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

-!- All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. -!- (cf. EC 2.7.11.14 and EC 2.7.11.15).

UniProtKB Entries (1)

P32298

GRK4_HUMAN

Homo sapiens

G protein-coupled receptor kinase 4

PDB Structure

PDB	4YHJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4. Allen, S.J., Parthasarathy, G., Darke, P.L., Diehl, R.E., Ford, R.E., Hall, D.L., Johnson, S.A., Reid, J.C., Rickert, K.W., Shipman, J.M., Soisson, S.M., Zuck, P., Munshi, S.K., Lumb, K.J. J.Biol.Chem.