CATH Domain 4yhjA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.16

[G-protein-coupled receptor] kinase.

based on mapping to UniProt P32298

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

-!- All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. -!- (cf. EC 2.7.11.14 and EC 2.7.11.15).

UniProtKB Entries (1)

P32298

GRK4_HUMAN

Homo sapiens

G protein-coupled receptor kinase 4

PDB Structure

PDB	4YHJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4. Allen, S.J., Parthasarathy, G., Darke, P.L., Diehl, R.E., Ford, R.E., Hall, D.L., Johnson, S.A., Reid, J.C., Rickert, K.W., Shipman, J.M., Soisson, S.M., Zuck, P., Munshi, S.K., Lumb, K.J. J.Biol.Chem.