CATH Domain 4yesB01

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Superfamily	Trypsin-like serine proteases
Functional Family	Prothrombin

3.4.21.5

Thrombin.

based on mapping to UniProt P00734

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.

-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

P00734	THRB_HUMAN Homo sapiens Prothrombin
P01050	HIRV1_HIRME Hirudo medicinalis Hirudin variant-1

PDB	4YES
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement. Chobanian, H.R., Pio, B., Guo, Y., Shen, H., Huffman, M.A., Madeira, M., Salituro, G., Terebetski, J.L., Ormes, J., Jochnowitz, N., Hoos, L., Zhou, Y., Lewis, D., Hawes, B., Mitnaul, L., O'Neill, K., Ellsworth, K., Wang, L., Biftu, T., Duffy, J.L. Acs Med.Chem.Lett.