CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.1110 | Calcium-transporting ATPase, transmembrane domain |
|
1.20.1110.10 | Calcium-transporting ATPase, transmembrane domain |
Domain Context
CATH Clusters
| Superfamily | Calcium-transporting ATPase, transmembrane domain |
| Functional Family | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
Enzyme Information
| 7.2.2.10 |
P-type Ca(2+) transporter.
based on mapping to UniProt P04191
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
-!- A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- This enzyme family comprises three types of Ca(2+)-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum, in yeast, and in some bacteria. -!- The enzymes from plasma membrane and from yeast have been shown to transport one ion per ATP hydrolyzed whereas those from the sarcoplasmic reticulum transport two ions per ATP hydrolyzed. -!- In muscle cells Ca(2+) is transported from the cytosol into the sarcoplasmic reticulum. -!- Formerly EC 3.6.1.38 and EC 3.6.3.8.
|
UniProtKB Entries (1)
| P04191 |
AT2A1_RABIT
Oryctolagus cuniculus
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
|
PDB Structure
| PDB | 4YCL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors
Proc.Natl.Acad.Sci.Usa
|
