CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.10 | Orthogonal Bundle |
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1.10.510 | Transferase(Phosphotransferase); domain 1 |
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1.10.510.10 | Transferase(Phosphotransferase) domain 1 |
Domain Context
CATH Clusters
Superfamily | Transferase(Phosphotransferase) domain 1 |
Functional Family | Cyclin-dependent kinase 1 |
Enzyme Information
2.7.11.22 |
Cyclin-dependent kinase.
based on mapping to UniProt P06493
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.
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2.7.11.23 |
[RNA-polymerase]-subunit kinase.
based on mapping to UniProt P06493
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
-!- Appears to be distinct from other protein phosphokinases. -!- Brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6. -!- Does not phosphorylate casein, phosvitin or histone. -!- Formerly EC 2.7.1.141.
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UniProtKB Entries (1)
P06493 |
CDK1_HUMAN
Homo sapiens
Cyclin-dependent kinase 1
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PDB Structure
PDB | 4YC6 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun
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