CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.10 | Jelly Rolls |
Domain Context
CATH Clusters
| Superfamily | Jelly Rolls |
| Functional Family | 2-hydroxyethylphosphonate dioxygenase |
Enzyme Information
| 1.13.11.72 |
2-hydroxyethylphosphonate dioxygenase.
based on mapping to UniProt Q5IW40
2-hydroxyethylphosphonate + O(2) = hydroxymethylphosphonate + formate.
-!- Isolated from some bacteria including Streptomyces hygroscopicus and Streptomyces viridochromogenes. -!- The pro-R hydrogen at C-2 of the ethyl group is retained by the formate ion. -!- Any stereochemistry at C-1 of the ethyl group is lost. -!- One atom from dioxygen is present in each product. -!- Involved in phosphinothricin biosynthesis.
|
UniProtKB Entries (1)
| Q5IW40 |
HEPD_STRVT
Streptomyces viridochromogenes DSM 40736
2-hydroxyethylphosphonate dioxygenase
|
PDB Structure
| PDB | 4YAR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A Common Late-Stage Intermediate in Catalysis by 2-Hydroxyethyl-phosphonate Dioxygenase and Methylphosphonate Synthase.
J.Am.Chem.Soc.
|