CATH Domain 4y76A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Coagulation factor X

Enzyme Information

3.4.21.6

Coagulation factor Xa.

based on mapping to UniProt P00742

Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.

-!- A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. -!- Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. -!- The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids. -!- Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00742

FA10_HUMAN

Homo sapiens

Coagulation factor X

PDB Structure

PDB	4Y76
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides. Chan, C., Borthwick, A.D., Brown, D., Burns-Kurtis, C.L., Campbell, M., Chaudry, L., Chung, C.W., Convery, M.A., Hamblin, J.N., Johnstone, L., Kelly, H.A., Kleanthous, S., Patikis, A., Patel, C., Pateman, A.J., Senger, S., Shah, G.P., Toomey, J.R., Watson, N.S., Weston, H.E., Whitworth, C., Young, R.J., Zhou, P. J. Med. Chem.