CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family | Thiamine thiazole synthase |
Enzyme Information
| 2.4.2.59 |
Sulfide-dependent adenosine diphosphate thiazole synthase.
based on mapping to UniProt Q58018
NAD(+) + glycine + sulfide = nicotinamide + ADP-5-ethyl-4-methylthiazole- 2-carboxylate + 3 H(2)O.
-!- This iron dependent enzyme, found in most archaea, is involved in the biosynthesis of thiamine phosphate. -!- The homologous enzyme from plants and fungi (EC 2.4.2.60) uses an intrinsic cysteine as sulfur donor and, unlike the archaeal enzyme, is a single turn-over enzyme.
|
UniProtKB Entries (1)
| Q58018 |
THI4_METJA
Methanocaldococcus jannaschii DSM 2661
Thiamine thiazole synthase
|
PDB Structure
| PDB | 4Y4M |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases.
Biochemistry
|