CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family |
Enzyme Information
| 2.4.2.60 |
Cysteine-dependent adenosine diphosphate thiazole synthase.
based on mapping to UniProt P32318
NAD(+) + glycine + [ADP-thiazole synthase]-L-cysteine = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]- dehydroalanine + 3 H(2)O.
-!- This iron dependent enzyme, found in fungi, plants, and some archaea, is involved in the thiamine phosphate biosynthesis pathway. -!- It is a single turn-over enzyme since the cysteine residue is not regenerated in vivo. -!- The homologous enzyme in archaea (EC 2.4.2.59) uses sulfide as sulfur donor.
|
UniProtKB Entries (1)
| P32318 |
THI4_YEAST
Saccharomyces cerevisiae S288C
Thiamine thiazole synthase
|
PDB Structure
| PDB | 4Y4L |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases.
Biochemistry
|