CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Sepiapterin reductase |
Enzyme Information
| 1.1.1.153 |
Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming).
based on mapping to UniProt P35270
(1) L-erythro-7,8-dihydrobiopterin + NADP(+) = sepiapterin + NADPH. (2) L-erythro-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8- tetrahydropterin + 2 NADPH.
-!- This enzyme catalyzes the final step in the de novo synthesis of tetrahydrobiopterin from GTP. -!- The enzyme, which is found in higher animals and some fungi and bacteria, produces the erythro form of tetrahydrobiopterin. -!- Cf. EC 1.1.1.325.
|
UniProtKB Entries (1)
| P35270 |
SPRE_HUMAN
Homo sapiens
Sepiapterin reductase
|
PDB Structure
| PDB | 4XWY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.
Neuron
|