CATH Domain 4xtwB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.930	BirA Bifunctional Protein; domain 2
	3.30.930.10	Bira Bifunctional Protein; Domain 2

Domain Context

CATH Clusters

Superfamily	Bira Bifunctional Protein; Domain 2
Functional Family

Enzyme Information

UniProtKB Entries (1)

I6YFP0_MYCTU

Mycobacterium tuberculosis H37Rv

Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (Biotin--protein ligase)

PDB Structure

PDB	4XTW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors. Bockman, M.R., Kalinda, A.S., Petrelli, R., De la Mora-Rey, T., Tiwari, D., Liu, F., Dawadi, S., Nandakumar, M., Rhee, K.Y., Schnappinger, D., Finzel, B.C., Aldrich, C.C. J.Med.Chem.