CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.940 | Eukaryotic RPB6 RNA polymerase subunit |
|
3.90.940.10 | RNA polymerase subunit, RPB6/omega |
Domain Context
CATH Clusters
| Superfamily | 3.90.940.10 |
| Functional Family | DNA-directed RNA polymerase subunit omega |
Enzyme Information
| 2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt A8ARN6
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
|
UniProtKB Entries (3)
| A8ARN6 |
RPOZ_CITK8
Citrobacter koseri ATCC BAA-895
DNA-directed RNA polymerase subunit omega
|
| P00579 |
RPOD_ECOLI
Escherichia coli K-12
RNA polymerase sigma factor RpoD
|
| A7ZUK1 |
RPOB_ECO24
Escherichia coli O139:H28 str. E24377A
DNA-directed RNA polymerase subunit beta
|
PDB Structure
| PDB | 4XSX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.
Proc.Natl.Acad.Sci.USA
|
