CATH Classification
Level | CATH Code | Description |
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2 | Mainly Beta |
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2.40 | Beta Barrel |
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2.40.10 | Thrombin, subunit H |
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2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
Superfamily | Trypsin-like serine proteases |
Functional Family | Urokinase-type plasminogen activator |
Enzyme Information
3.4.21.73 |
U-plasminogen activator.
based on mapping to UniProt P00749
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- Formed from the inactive precursor by action of plasmin or plasma kallikrein. -!- Differs in structure from EC 3.4.21.68, and does not bind to fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.
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UniProtKB Entries (1)
P00749 |
UROK_HUMAN
Homo sapiens
Urokinase-type plasminogen activator
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PDB Structure
PDB | 4XSK |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure of PAItrap, an uPA mutant
To Be Published
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