CATH Classification
Level | CATH Code | Description |
---|---|---|
![]() |
3 | Alpha Beta |
![]() |
3.30 | 2-Layer Sandwich |
![]() |
3.30.572 | Thymidylate Synthase; Chain A |
![]() |
3.30.572.10 | Thymidylate synthase/dCMP hydroxymethylase domain |
Domain Context
CATH Clusters
Superfamily | Thymidylate synthase/dCMP hydroxymethylase domain |
Functional Family | Possible thymidylate synthase |
Enzyme Information
2.1.1.45 |
Thymidylate synthase.
based on mapping to UniProt Q4JQW2
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
|
UniProtKB Entries (1)
Q4JQW2 |
TYSY_VZVO
Human herpesvirus 3 strain Oka vaccine
Thymidylate synthase
|
PDB Structure
PDB | 4XSC |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine.
Plos One
|