CATH Domain 4xs2A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Interleukin-1 receptor-associated kinase 4

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q9NWZ3

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9NWZ3

IRAK4_HUMAN

Homo sapiens

Interleukin-1 receptor-associated kinase 4

PDB Structure

PDB	4XS2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4. McElroy, W.T., Michael Seganish, W., Jason Herr, R., Harding, J., Yang, J., Yet, L., Komanduri, V., Prakash, K.C., Lavey, B., Tulshian, D., Greenlee, W.J., Sondey, C., Fischmann, T.O., Niu, X. Bioorg.Med.Chem.Lett.