CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.360 | Dihydrodipicolinate Reductase; domain 2 |
|
3.30.360.30 | homospermidine synthase like |
Domain Context
CATH Clusters
| Superfamily | homospermidine synthase like |
| Functional Family |
Enzyme Information
| 2.5.1.44 |
Homospermidine synthase.
based on mapping to UniProt O32323
(1) 2 putrescine = sym-homospermidine + NH(3) + H(+). (2) Putrescine + spermidine = sym-homospermidine + propane-1,3-diamine.
-!- The reaction of this enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: NAD(+)-dependent dehydrogenation of putrescine, transfer of the 4-aminobutylidene group from dehydroputrescine to a second molecule of putrescine and reduction of the imine intermediate to form homospermidine. -!- Hence the overall reaction is transfer of a 4-aminobutyl group. -!- Differs from EC 2.5.1.45, which cannot use putrescine as donor of the aminobutyl group.
|
UniProtKB Entries (1)
| O32323 |
HSS_BLAVI
Blastochloris viridis
Homospermidine synthase
|
PDB Structure
| PDB | 4XR4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Comprehensive Structural Characterization of the Bacterial Homospermidine Synthase-an Essential Enzyme of the Polyamine Metabolism.
Sci Rep
|