CATH Domain 4xgsA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1260	Ferritin
	1.20.1260.10	Ferritin, core subunit, four-helix bundle

Domain Context

CATH Clusters

Superfamily	1.20.1260.10
Functional Family	Non-heme ferritin

Enzyme Information

1.16.3.2

Bacterial non-heme ferritin.

based on mapping to UniProt P0A998

4 Fe(2+) + O(2) + 6 H(2)O = 4 (FeO(OH)) + 8 H(+).

-!- Ferritins are intracellular iron-storage and detoxification proteins found in all kingdoms of life. -!- They are formed from two subunits that co-assemble in various ratios to form a spherical protein shell. -!- Thousands of mineralized iron atoms are stored within the core of the structure. -!- The product of dioxygen reduction by the bacterial non-heme ferritin is hydrogen peroxide, which is consumed in a subsequent reaction.

UniProtKB Entries (1)

P0A998

FTNA_ECOLI

Escherichia coli K-12

Bacterial non-heme ferritin

PDB Structure

PDB	4XGS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria Kim, S., Lee, J.H., Seok, J.H., Park, Y.H., Jung, S.W., Cho, A.E., Lee, C., Chung, M.S., Kim, K.H. J. Mol. Biol.