CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
6 | Special |
|
6.10 | Helix non-globular |
|
6.10.240 | ProC C-terminal domain-like fold |
|
6.10.240.10 |
Domain Context
CATH Clusters
| Superfamily | 6.10.240.10 |
| Functional Family |
Enzyme Information
| 1.1.1.383 |
Ketol-acid reductoisomerase (NAD(P)(+)).
based on mapping to UniProt E0SRA9
(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(P)(+) = (2S)-2-hydroxy-2- methyl-3-oxobutanoate + NAD(P)H.
-!- The enzyme, characterized from the bacteria Hydrogenobaculum sp. and Syntrophomonas wolfei subsp. wolfei and from the archaea Metallosphaera sedula and Ignisphaera aggregans, can use both NADH and NADPH with similar efficiency (cf. EC 1.1.1.86 and EC 1.1.1.382).
|
UniProtKB Entries (1)
| E0SRA9 |
ILVC_IGNAA
Ignisphaera aggregans DSM 17230
Ketol-acid reductoisomerase (NAD(P)(+))
|
PDB Structure
| PDB | 4XDZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases.
Biochem.J.
|