CATH Domain 4xcxA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family	HEN methyltransferase 1

Enzyme Information

2.1.1.n8

Small RNA 2'-O-methyltransferase.

based on mapping to UniProt Q5T8I9

S-adenosyl-L-methionine + small RNA = S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide.

-!- Adds a methyl group to the ribose of the last nucleotide of small RNAs (sRNAs). -!- This protects the 3'-end of sRNAs from uridylation activity and subsequent degradation. -!- Can methylates 3'-end of microRNAs (miRNAs), small interfering RNAs (siRNas) and trans-acting small interfering RNAs (ta-siRNAs).

UniProtKB Entries (1)

Q5T8I9

HENMT_HUMAN

Homo sapiens

Small RNA 2'-O-methyltransferase

PDB Structure

PDB	4XCX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of human C1ORF59 in complex with SAH Walker, J.R., Zeng, H., Dong, A., Li, Y., Wernimont, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC) To be published