CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.40 | Immunoglobulin-like |
|
2.60.40.1700 | Protein-arginine deiminase, central domain |
Domain Context
CATH Clusters
| Superfamily | Protein-arginine deiminase, central domain |
| Functional Family | Protein-arginine deiminase type-2 |
Enzyme Information
| 3.5.3.15 |
Protein-arginine deiminase.
based on mapping to UniProt Q9UM07
Protein L-arginine + H(2)O = protein L-citrulline + NH(3).
-!- Also acts on N-acyl-L-arginine and, more slowly, on L-arginine esters.
|
UniProtKB Entries (1)
| Q9UM07 |
PADI4_HUMAN
Homo sapiens
Protein-arginine deiminase type-4
|
PDB Structure
| PDB | 4X8C |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Nat.Chem.Biol.
|
