CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1410 | Poly(a)-polymerase, middle domain |
|
1.10.1410.30 | CCA tRNA nucleotidyltransferase, domain 2 |
Domain Context
CATH Clusters
| Superfamily | CCA tRNA nucleotidyltransferase, domain 2 |
| Functional Family |
Enzyme Information
| 2.7.7.72 |
CCA tRNA nucleotidyltransferase.
based on mapping to UniProt O28126
A tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate.
-!- The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3' CCA sequence. -!- The CCA sequence is added to the tRNA precursor by stepwise nucleotide addition performed by a single enzyme that is ubiquitous in all living organisms. -!- Although the enzyme has the option of releasing the product after each addition, it prefers to stay bound to the product and proceed with the next addition. -!- Formerly EC 2.7.7.21 and EC 2.7.7.25.
|
UniProtKB Entries (1)
| O28126 |
CCA_ARCFU
Archaeoglobus fulgidus DSM 4304
CCA-adding enzyme
|
PDB Structure
| PDB | 4X4P |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme.
Cell
|
