CATH Domain 4wxbC01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1150	Aspartate Aminotransferase, domain 1
	3.90.1150.10	Aspartate Aminotransferase, domain 1

Domain Context

CATH Clusters

Superfamily	Aspartate Aminotransferase, domain 1
Functional Family	Serine hydroxymethyltransferase

Enzyme Information

2.1.2.1

Glycine hydroxymethyltransferase.

based on mapping to UniProt Q5M0B4

5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.

-!- Also catalyzes the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy- N(6),N(6),N(6)-trimethyl-L-lysine.

UniProtKB Entries (1)

Q5M0B4

GLYA_STRT1

Streptococcus thermophilus CNRZ1066

Serine hydroxymethyltransferase

PDB Structure

PDB	4WXB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Engineered L-Serine Hydroxymethyltransferase from Streptococcus thermophilus for the Synthesis of alpha , alpha-Dialkyl-alpha-Amino Acids. Hernandez, K., Zelen, I., Petrillo, G., Uson, I., Wandtke, C.M., Bujons, J., Joglar, J., Parella, T., Clapes, P. Angew.Chem.Int.Ed.Engl.