CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.780 | 5'-nucleotidase; domain 2 |
|
3.90.780.10 | 5'-Nucleotidase, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | 5'-Nucleotidase, C-terminal domain |
| Functional Family | Protein UshA |
Enzyme Information
| 3.6.1.45 |
UDP-sugar diphosphatase.
based on mapping to UniProt P07024
UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate.
-!- UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. -!- Thus, this enzyme has a specificity distinct from that of EC 3.6.1.21. -!- Some but not all enzymes of this class also appear to have EC 3.1.3.5 activity.
|
| 3.1.3.5 |
5'-nucleotidase.
based on mapping to UniProt P07024
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
-!- Wide specificity for 5'-nucleotides.
|
UniProtKB Entries (1)
| P07024 |
USHA_ECOLI
Escherichia coli K-12
Protein UshA
|
PDB Structure
| PDB | 4WWL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
E. coli 5'-nucleotidase mutant I521C labeled with MTSL (intermediate form)
To Be Published
|